Trifexis® (spinosad + milbemycin oxime) for Dogs

Trifexis ® is a beef-flavored tablet that kills fleas and prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm and whipworm infections.

Why choose Trifexis ® for your dog?

Kills fleas on dogs and prevents infestations Prevents heartworm disease in dogs Treats and controls hookworm, roundworm and whipworm infections

Give parasites in dogs a one-two punch

Protects against:

Fleas, heartworm disease, hookworms, roundworms and whipworms

Works for:

Dogs and puppies 8 weeks and older and 5 pounds or greater

Form:

Easy-to-administer beef-flavored tablet

Dosing frequency: Requires prescription

A dog walking through a clear tunnel

Tailored to a range of dog weights

Trifexis® is available in five different strengths according to weight and is safe when used according to the label directions for pup through to adult.

An owner picking up after a dog

How much do you know about intestinal worms?

You may have heard about intestinal worms, but how much do you know about the threat to your dog? Learn more.

Trifexis® product packages

Where to buy Trifexis®

Protect your dog all month long from fleas, heartworm disease and intestinal parasites with Trifexis®.

Protects against:

Fleas, heartworm disease, hookworms, roundworms and whipworms

Works for:

Dogs and puppies 8 weeks and older and 5 pounds or greater

Form:

Easy-to-administer beef-flavored tablet

Dosing frequency: Requires prescription

A dog walking through a clear tunnel

Tailored to a range of dog weights

Trifexis® is available in five different strengths according to weight and is safe when used according to the label directions for pup through to adult.

An owner picking up after a dog

How much do you know about intestinal worms?

You may have heard about intestinal worms, but how much do you know about the threat to your dog? Learn more.

Trifexis® product packages

Where to buy Trifexis®

Protect your dog all month long from fleas, heartworm disease and intestinal parasites with Trifexis®.

Protects against:

Fleas, heartworm disease, hookworms, roundworms and whipworms

Works for:

Dogs and puppies 8 weeks and older and 5 pounds or greater

Form:

Easy-to-administer beef-flavored tablet

Dosing frequency: Requires prescription

A dog walking through a clear tunnel

Tailored to a range of dog weights

Trifexis® is available in five different strengths according to weight and is safe when used according to the label directions for pup through to adult.

An owner picking up after a dog

How much do you know about intestinal worms?

You may have heard about intestinal worms, but how much do you know about the threat to your dog? Learn more.

Trifexis® product packages

Where to buy Trifexis®

Protect your dog all month long from fleas, heartworm disease and intestinal parasites with Trifexis®.

Ready to protect your dog from heartworm disease, intestinal worms and fleas?

Top questions about Trifexis ®

Do I have to give Trifexis with food?

Administer Trifexis with food for maximum effectiveness. Trifexis is a chewable beef-flavored tablet that can be given as a treat.

Does seeing fleas on my dog mean the treatment is not working?

Trifexis kills fleas on dogs before they can lay eggs when used monthly and according to the label directions. Remember that all animals in the household should be treated with an approved flea product to help control the flea population. Your dog can continue to be exposed to fleas that live in the environment. When fleas jump onto and bite your dog, they will be killed by Trifexis. If, within a month after your dog receives Trifexis, you see fleas on your dog, they are most likely new fleas. These new fleas will be killed before they can produce eggs that contaminate the environment. Continued monthly use of Trifexis can protect against any new infestations.

What if I see worms in my dog’s stool during the month after administration of Trifexis?

Trifexis is indicated to treat and control intestinal parasite infections of adult hookworms, roundworms and whipworms in dogs. In occasional cases, it is possible that you might see intestinal worms being expelled in your dog’s stool — this means Trifexis is working. If you have questions, consult your veterinarian for measures you can take to prevent a reinfection of intestinal parasites.

What are the active ingredients in Trifexis?

Spinosad and milbemycin oxime are the two active ingredients in Trifexis.

If spinosad kills fleas, is it safe for my dog?

Trifexis has been demonstrated to be safe in healthy dogs when used according to label directions. Spinosad, one of its active ingredients, is produced by a bacterium first isolated from natural sources (a soil sample collected in the Caribbean). 1

1. Spinosad selectively targets the nervous system of the flea (and other insects) due to differences in the targeted receptors compared to mammalian nervous systems. 2

2. However, as with all medications, sensitivities in individual animals can occur, sometimes resulting in side effects. See the Trifexis label for complete safety information.

Can Trifexis be given to cats?

No, Trifexis is not approved for use in cats. Trifexis was developed exclusively for administration to dogs.

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Trifexis, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.

Safety Information References

Indications

Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.

Important Safety Information

The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.

  1. Sparks, TC et al Humana Press 1999 171 (v1.0)
  2. Dow Agro Sciences Spinosad Technical Manual 2001 (v1.0)