- J Biol Chem. 2016 Dec 23;291(52):26886-26898 - PubMed
- PLoS Pathog. 2009 May;5(5):e1000437 - PubMed
- J Med Genet. 2007 Jul;44(7):472-7 - PubMed
- J Biol Chem. 2001 Nov 9;276(45):42003-10 - PubMed
- Science. 2002 Apr 26;296(5568):755-8 - PubMed
Alterations in the regulation of gene expression are frequently associated with developmental diseases or cancer. Transcription activation is a key phenomenon in the regulation of gene expression. In all eukaryotes, mediator of RNA polymerase II transcription (Mediator), a large complex with modular organization, is generally required for transcription by RNA polymerase II, and it regulates various steps of this process. The main function of Mediator is to transduce signals from the transcription activators bound to enhancer regions to the transcription machinery, which is assembled at promoters as the preinitiation complex (PIC) to control transcription initiation. Recent functional studies of Mediator with the use of structural biology approaches and functional genomics have revealed new insights into Mediator activity and its regulation during transcription initiation, including how Mediator is recruited to transcription regulatory regions and how it interacts and cooperates with PIC components to assist in PIC assembly. Novel roles of Mediator in the control of gene expression have also been revealed by showing its connection to the nuclear pore and linking Mediator to the regulation of gene positioning in the nuclear space. Clear links between Mediator subunits and disease have also encouraged studies to explore targeting of this complex as a potential therapeutic approach in cancer and fungal infections.
Petrenko N, Jin Y, Wong KH, Struhl K. Petrenko N, et al. Mol Cell. 2016 Nov 3;64(3):443-454. doi: 10.1016/j.molcel.2016.09.015. Epub 2016 Oct 20. Mol Cell. 2016. PMID: 27773675 Free PMC article.
Freytes SN, Gobbini ML, Cerdán PD. Freytes SN, et al. Annu Rev Plant Biol. 2024 Jul;75(1):211-237. doi: 10.1146/annurev-arplant-070623-114005. Epub 2024 Jul 2. Annu Rev Plant Biol. 2024. PMID: 38277699 Review.
Eychenne T, Werner M, Soutourina J. Eychenne T, et al. Transcription. 2017;8(5):328-342. doi: 10.1080/21541264.2017.1329000. Epub 2017 Aug 25. Transcription. 2017. PMID: 28841352 Free PMC article. Review.
Petrenko N, Jin Y, Wong KH, Struhl K. Petrenko N, et al. Elife. 2017 Jul 12;6:e28447. doi: 10.7554/eLife.28447. Elife. 2017. PMID: 28699889 Free PMC article.
Borggrefe T, Yue X. Borggrefe T, et al. Semin Cell Dev Biol. 2011 Sep;22(7):759-68. doi: 10.1016/j.semcdb.2011.07.022. Epub 2011 Aug 4. Semin Cell Dev Biol. 2011. PMID: 21839847 Review.
Huang S, Hu J, Hu M, Hou Y, Zhang B, Liu J, Liu X, Chen Z, Wang L. Huang S, et al. Oncogene. 2024 Aug 22. doi: 10.1038/s41388-024-03126-w. Online ahead of print. Oncogene. 2024. PMID: 39174859
Hyder U, Challa A, Thornton M, Nandu T, Kraus WL, D'Orso I. Hyder U, et al. Nat Commun. 2024 Jul 12;15(1):5859. doi: 10.1038/s41467-024-49905-7. Nat Commun. 2024. PMID: 38997286 Free PMC article.
Zhao H, Li J, Xiang Y, Malik S, Vartak SV, Veronezi GMB, Young N, Riney M, Kalchschmidt J, Conte A, Jung SK, Ramachandran S, Roeder RG, Shi Y, Casellas R, Asturias FJ. Zhao H, et al. Mol Cell. 2024 Jul 25;84(14):2648-2664.e10. doi: 10.1016/j.molcel.2024.06.006. Epub 2024 Jul 1. Mol Cell. 2024. PMID: 38955181
Wang C, Zhang X, Wu K, Liu S, Li X, Zhu C, Xiao Y, Fang Z, Liu J. Wang C, et al. Appl Environ Microbiol. 2024 Jul 24;90(7):e0054524. doi: 10.1128/aem.00545-24. Epub 2024 Jun 20. Appl Environ Microbiol. 2024. PMID: 38899887
Cui Y, Su Y, Bian J, Han X, Guo H, Yang Z, Chen Y, Li L, Li T, Deng XW, Liu X. Cui Y, et al. Plant Commun. 2024 Aug 12;5(8):100979. doi: 10.1016/j.xplc.2024.100979. Epub 2024 May 24. Plant Commun. 2024. PMID: 38794796 Free PMC article.